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Psychotropic Drug Information Newsletter
 
 




 


 

 
  Psychotropic Drug Information Letter  
     
 

The German Journal of Psychiatry
Psychotropic Drug Information Newsletter

 
     
  Stefan Kropp, MD, Clinical Psychiatry and Psychotherapy, Hannover School of Medicine, Germany  
     
  Comments are welcome via email: kropp.stefan@mh-hannover.de  
     
 
September 2002
 
     
   
     
  Dear colleagues and readers,  
     
  please find enclosed more readings which might be useful for your clinical administration of psychotropic drug therapy. As before the drug information focuses on drug interactions, side-effects or new effects of known psychotropics.  
     
  Neuroleptics:  
     
  Ziprasidone an Alternative for Olanzapine-Induced Hyperglycemia? In this case-report, an new-onset diabetes under olanzapine vanished and the patient had normal fasting blood glucose levels after change to Ziprasidone. Am J Psychiatry 2002;159: 1606  
     
  Myocarditis with Quetiapine? First case report of a possible quetiapine-related myocarditis. Am J Psychiatry 2002;159: 1607  
     
  Switching Antipsychotic Medication: General Recommendations and Switching to Amisulpride. Curr Med Res Opin 2002;18:201-208 (also via www.medscape.com)  
     
  Risperidon Consta® available in Germany for the labeled use in schizophrenia.  
     
  Metoclopramide-Induced Supersensitivity Psychosis. To case-reports: after discontinuation two men developed hallucinations and delusions. Ann Pharmacother 2002; 36:1387-1390  
     
  Miscellaneous:  
     
  Ginkgo-biloba extracts associated with the risk of bleeding. As Ginkgo is an „over the conter“ medication, prescribing physicians need the information if any profibrinolytic drugs (as Ginkgo) are already given to their patient. Dt Ärzteblatt 2002; Jg. 99; Heft 33: A 2214  
     
  Hawaiian baby woodrose: (Psycho-) Pharmacological effects of the seeds of Argyreia nervosa. A Case-report. Nervenarzt 2002 73: 892–896  
     
  Transient global amnesia after sildenafil (Viagra) use (letter). Neurology 2002; 59: 778  
     
 
Helpful suggestions came from: Thomas Huber, MD; Horst Haltenhof, MD
 
     
 
August 2002
 
     
  Dear colleagues and readers,  
     
  please find enclosed more readings which might be useful for your clinical administration of psychotropic drug therapy. As before the drug information focuses on drug interactions, side-effects or new effects of known psychotropics.  
     
  Neuroleptics:  
     
  Ziprasidone: the first adverse events from the American Journal of Psychiatry including Rhabdomyolysis. Pancreatitis, Hyperglycemia, Migraine (?) and Dyskinesia. Am J Psychiatry 2002; 159: 1436-1436  
     
  Antidepressants:  
     
  Guidelines for the right choice /avoidance of certain food in combination with Jatrosom N®. www.esparma.de  
     
  Mirtazapine overdose with benign outcome. Case report and references with other cases: Mirtazapine appears to be relatively safe in overdosing. Raja M, Azzoni A. Eur Psychiatry 2002; 17:107  
     
  SSRIs increase the risk of upper gastrointestinal bleeding because SSRIs decrease the amount of serotonin in platelets. The patients with the highest risk might be those with an upper gastrointestinal bleeding. Van Walraven et al. BMJ 2001; 323:1-6  
     
  Miscellaneous:  
     
  ?Off label use in psychopharmacotherapy. Discussion paper of the DGPPN concerning new directives of the health insurances. Fritze J, Schmauß M. Nervenarzt 2002;8: 796-799  
   
  Spontaneous dyskinesia and parkinsonism in never medicated, chronically ill patients with schizophrenia. A follow-up. McCreadie et al. Br J Psychiatry 2002; 181: 135-137Spontaneous dyskinesia and parkinsonism in never medicated, chronically ill patients with schizophrenia. A follow-up. McCreadie et al. Br J Psychiatry 2002; 181: 135-137  
     
 
Helpful suggestions came from: Horst Haltenhof, MD;
 
     
 
July 2002
 
     
  Neuroleptics:  
     
  Sudden unexplained death in psychiatric in-patients related to hypertension, ischemic heart disease and current treatment with thioridazine but not with other antipsychotic drugs. Reilly et al. Br J Psychiatry 2002; 189: 515-522  
   
  Possible neuroleptic malignant syndrome with quetiapine? (letter). Sing et al. Am J Psychiatry 2002; 159: 149-150  
   
  Clozapine-hexal without controlled administration. Drug precribing physicians don’t need to register if they precribe the drug in contrast to Leponex® or Elcrit®. No change in laboratory makeup or safety procedures. Source: Hexal phamaceuticals 7-2002.  
     
  Antidepressants:  
     
  Liver failure due to intake of 150 mg Nefazodone b.i.d.? Case report. Ehrentraut et al. Nervenarzt 2002; 73:686-689  
     
  Miscellaneous:  
     
  Kava-Kava products because of hepatotocicity withdrawn from German market. Source: http://www.bfarm.de/de_ver/arzneimittel/amrisiken/stufenplan/Besch-Kava-Final.pdf  
   
  No justification not to treat patients with interferon alfa when psychiatric diseases are preexisting. Pariante CM, et al. N Engl J Med 2002; 347: 148-149 (letter)  
   
  Akatinol Memantine® will be renamed Axura® and Ebixa® in Germany starting August 1st. Source: Merz and Lundbeck Pharmaceuticals.  
   
  Interactions between Psychotropics, Anaestetics and ECT (very helpful review for all possible interactions for the clinical practice which might include ECT). Naguib and Koorn, CNS Drugs 2002; 16: 229-247  
     
 
Helpful suggestions came from: Horst Haltenhof, MD; Detlef Dietrich, MD;
 
     
 
June 2002
 
     
  Neuroleptics:  
     
  Asymptomatic Bradycardia Associated with Amisulpride (case-report). Pedrosa Gil et al. Pharmacopsychiatry 2001; 34: 259-261  
   
  Comparison of Weight, Lipid and Glucose Changes between Risperidone and Olanzapine (Original Conrtibution): Meyer. J Clin Psychiatry 2002; 63: 425-433  
   
  Bradycardia and Hypoxia with Amisulpride (letter). Züchner: Dtsch Med Wochschr 2002; 127:983  
   
  Priapism Associated with Zuclopentixol (Case-Report): Salado et al: Ann Pharmacother 2002; 36: 1016-1018  
   
  Sudden late Onset of Clozapine-Induced Agranulocytosis: Ann Pharmacother 2002; 36: 1012-1015  
   
  Cytochrome P450 2D6 Deficiency and ist Clinical relevance in a Patient treated with Risperidone: Köhnke et al, Pharmacopsychiatry 2002; 35: 116-118  
     
  Antidepressants:  
     
  Citalopram Overdose with 600 mg with bradycardia and therapy with a temporary pacemaker (case report). Rothenhäusler et al: Pharmacopsychiatry 2002: 33: 150-152  
   
  Fluvoxamine: Safety profile in Extensive Postmarketing Surveillance. Buchberger and Wagner, Pharmacopsychiatry 2002; 35: 101-108  
     
  Miscellaneous:  
     
  Drug induced QT-prolongation and Torsade-de-Pointes arrhythmia. (Overview on proarrythmetic drugs or combinations, relevant for practical drug prescribing) Haffner et al. Dtsch Med Wochschr 2002; 127:1022-1024  

   
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